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Proteins and Peptides

AY-NH2

Product Sizes
AY-NH2
£129.00
PR-020
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
PR-020
Additional Names:
AYPGKF-NH2
CAS Number:
352017-71-1
Extra Details:
AY-NH2, also known as AYPGKF-NH2, is a selective PAR4 receptor agonist peptide.  AY-NH2 stimulates platelet aggregation in vitro with an EC50 of 15 μM and can cause an increase in paw thickness in the paw edema inflammation model.
Molecular Weight:
680.8
Purity:
>95% by hplc
References:
<p>Faruqi et al (2000) Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. <strong>275</strong> 19728 <a href="https://pubmed.ncbi.nlm.nih.gov/10779527/" target="_blank" rel="nofollow">PMID: 10779527</a></p><p>Palygin et al (2016), Protease-activated Receptor-1-driven Intracellular Calcium Dynamics in Rat Glomerular Podocytes. FASEB J. <strong>30</strong> 968.25 <a href="https://pubmed.ncbi.nlm.nih.gov/27733370/" target="_blank" rel="nofollow">PMID: 27733370</a></p><p>Meyer et al (2020) Platelet Interactions with Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells Lead to Hepatocyte Proliferation. Cells <strong>9</strong>(5) 1243 <a href="https://pubmed.ncbi.nlm.nih.gov/32443494/" target="_blank" rel="nofollow">PMID: 32443494</a></p>
Sequence:
H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2
Shipping Conditions:
Ambient
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Solubility:
Soluble to 2 mg/ml in water
Formula:
C34H48N8O7