Ac2-26
About this Product
- SKU:
- PP-100
- Additional Names:
- AnxA1 mimetic peptide, Lipocortin-1 (2-26), Annexin-1 (2-26) (human)
- CAS Number:
- 151988-33-9
- Extra Details:
- Ac2-26 is the N terminal fragment of annexin A1 and an annexin/lipocortin 1 mimetic. Ac2-26 can inhibit leukocyte extravasation, reduce neutrophil adhesion and emigration, promote detachment of neutrophils from activated mesenteric endothelium and accelerate epithelial wound repair. Local intestinal delivery of Ac2-26 encapsulated within targeted polymeric nanoparticles accelerates healing of murine colonic wounds after biopsy-induced injury.
- Molecular Weight:
- 3089.46
- Purity:
- >95% by hplc
- References:
- <p>Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. <strong>18</strong> 60 <a href="https://pubmed.ncbi.nlm.nih.gov/12644621/" target="_blank" rel="nofollow">PMID: 12644621</a></p><p>Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. <strong>125</strong> 1215 <a href="https://pubmed.ncbi.nlm.nih.gov/25664854/" target="_blank" rel="nofollow">PMID: 25664854</a></p><p>Possebon et al (2018) Mimetic peptide AC2-26 of annexin A1 as a potential therapeutic agent to treat COPD, International Immunopharmacology, <strong>63</strong> 270 <a href="https://pubmed.ncbi.nlm.nih.gov/30121452/" target="_blank" rel="nofollow">PMID: 30121452</a></p>
- Sequence:
- Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in phosphate buffered saline
- Formula:
- C141H210N32O44S