Ac-DEVD-AMC
Product Sizes
Ac-DEVD-AMC
£87.00
PI-260
About this Product
- SKU:
- PI-260
- CAS Number:
- 169332-61-0
- Extra Details:
- Ac-DEVD-AMC is a fluorogenic substrate for caspase-3 with a Km value of 9.7 ± 1.0 μM. The sequence of Ac-DEVD-AMC is based on the PARP cleavage site Asp216 for caspase-3 and it is also a substrate for caspases -1, -4, -7 and -8. Ac-DEVD-AMC can be used to monitor intracellular caspase activity with cleaved AMC moieties, reflecting caspase activity, being detected by fluorescence.
- Molecular Weight:
- 675.7
- Purity:
- >97% (HPLC)
- References:
- <p>Nicholson et al (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature <strong>376</strong>(6535) 37 <a href="https://pubmed.ncbi.nlm.nih.gov/7596430/" target="_blank" rel="nofollow">PMID: 7596430</a></p><p>Alsuwaidi et al (2013) Bioenergetics of murine lungs infected with respiratory syncytial virus. Virol. J. <strong>10</strong> 22 <a href="https://pubmed.ncbi.nlm.nih.gov/23320837/" target="_blank" rel="nofollow">PMID: 23320837</a></p><p>Alsuwaidi et al (2013) Lung tissue bioenergetics and caspase activity in rodents. BMC Res Notes<strong> 6</strong> 12 <a href="https://pubmed.ncbi.nlm.nih.gov/23311890/" target="_blank" rel="nofollow">PMID: 23311890</a></p>
- Sequence:
- Ac-Asp-Glu-Val-Asp-AMC
- Shipping Conditions:
- Ambient
- Storage Conditions:
- We recommend storage desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in DMSO; dilute with buffer for use
- Formula:
- C30H37N5O13