Autocamtide-2-related inhibitory peptide
Product Sizes
Autocamtide-2-related inhibitory peptide
£176.00
KS-190
About this Product
- SKU:
- KS-190
- Additional Names:
- AIP
- CAS Number:
- 167114-91-2
- Extra Details:
- Autocamtide-2-related inhibitory peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor with an IC50 of 40 nM. Autocamtide-2-related inhibitory peptide is selective over PKC, PKA and CaM kinase IV, with IC50's greater than 10 μM for each. Autocamtide 2-related inhibitory peptide reverses CaMKII mediated effects in cardiac channels but does not alter INa gating.
- Molecular Weight:
- 1497.76
- Purity:
- >95% by hplc
- References:
- <p>Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun.<strong> 212</strong> 806 <a href="https://pubmed.ncbi.nlm.nih.gov/7626114/" target="_blank" rel="nofollow">PMID: 7626114</a></p><p>Wagner et al (2006) Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest. <strong>116</strong>(12) 3127<a href="https://www.jci.org/articles/view/26620" target="_blank" rel="nofollow"> https://doi.org/10.1172/JCI26620.</a><br></p><p>Ikeda et al (2019) Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway. Sci Rep <strong>9</strong> 9850 <a href="https://www.nature.com/articles/s41598-019-46367-6" target="_blank">https://doi.org/10.1038/s41598-019-46367-6</a></p>
- Sequence:
- H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C64H116N22O19