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Proteins and Peptides

Autocamtide-2-related inhibitory peptide

Product Sizes
Autocamtide-2-related inhibitory peptide
£176.00
KS-190
Academic Pricing
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About this Product
SKU:
KS-190
Additional Names:
AIP
CAS Number:
167114-91-2
Extra Details:
Autocamtide-2-related inhibitory peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor with an IC50 of 40 nM.  Autocamtide-2-related inhibitory peptide is selective over PKC, PKA and CaM kinase IV, with IC50's greater than 10 μM for each.  Autocamtide 2-related inhibitory peptide reverses CaMKII mediated effects in cardiac channels but does not alter INa gating.
Molecular Weight:
1497.76
Purity:
>95% by hplc
References:
<p>Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun.<strong> 212</strong> 806 <a href="https://pubmed.ncbi.nlm.nih.gov/7626114/" target="_blank" rel="nofollow">PMID: 7626114</a></p><p>Wagner et al (2006) Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels.  J Clin Invest. <strong>116</strong>(12) 3127<a href="https://www.jci.org/articles/view/26620" target="_blank" rel="nofollow"> https://doi.org/10.1172/JCI26620.</a><br></p><p>Ikeda et al (2019) Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway. Sci Rep <strong>9</strong> 9850  <a href="https://www.nature.com/articles/s41598-019-46367-6" target="_blank">https://doi.org/10.1038/s41598-019-46367-6</a></p>
Sequence:
H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
Shipping Conditions:
Ambient
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Solubility:
Soluble to 1 mg/ml in water
Formula:
C64H116N22O19