ATN 161
About this Product
- SKU:
- IG-040
- CAS Number:
- 262438-43-7
- Extra Details:
- ATN 161 is a α5β1 integrin receptor antagonist that also binds to several other integrins, including α5β1 and αvβ3. ATN 161 is a 5-mer capped peptide derived from the synergy region (PHSRN) of human fibronectin, in which a cysteine residue replaces an arginine in the original sequence (PHSCN). ATN 161 has been shown to inhibit tumour growth, angiogenesis and metastasis and extend survival in multiple animal tumours, it has also shown activity outside oncology and can regress established Crohn's disease in several animal models.
- Molecular Weight:
- 597.65
- Purity:
- >95% by hplc
- References:
- <p>Livant et al (2000) Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res.<strong> 60</strong> 309 <a href="https://pubmed.ncbi.nlm.nih.gov/10667582/" target="_blank" rel="nofollow">PMID: 10667582</a></p><p>Khalili et al (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. <strong>5</strong> 2271 <a href="https://pubmed.ncbi.nlm.nih.gov/16985061/" target="_blank" rel="nofollow">PMID: 16985061</a></p><p>Doñate (2008) Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth. Clin Cancer Res. <strong>14</strong>(7) 2137 <a href="https://pubmed.ncbi.nlm.nih.gov/18381955/" target="_blank">PMID: 18381955</a><br></p>
- Sequence:
- Ac-Pro-His-Ser-Cys-Asn-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 5 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 2 mg/ml in water
- Formula:
- C23H35N9O8S