ATI 2341
About this Product
- SKU:
- CK-010
- CAS Number:
- 1337878-62-2
- Extra Details:
- ATI 2341 is a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR) at which it is an allosteric agonist with an EC50 of 194 nM. ATI 2341 functions as a biased ligand, favouring Gαi activation over Gα13. In contrast to the the natural CXCR4 agonist, stromal cell-derived factor-1α, ATI 2341 does not promote β-arrestin recruitment. ATI 2341 induces chemotaxis in CXCR4 expressing cells in vitro and acts as a functional antagonist to mobilise polymorphonuclear neutrophils and hematopoietic stem and progenitor cells from bone marrow niche in both mice and non-human primates.
- Molecular Weight:
- 2256.82
- Purity:
- >95% by hplc
- References:
- <p>Tchernychev et al (2010) Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. <strong>107</strong> 22255 <a href="https://pubmed.ncbi.nlm.nih.gov/21139054/" target="_blank" rel="nofollow">PMID: 21139054</a></p><p>Quoyer et al (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. <strong>110</strong> E5088 <a href="https://pubmed.ncbi.nlm.nih.gov/24309376/" target="_blank" rel="nofollow">PMID: 24309376</a></p><p>Planesas et al (2015) Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. <strong>6</strong>0 1 <a href="https://pubmed.ncbi.nlm.nih.gov/26080355/" target="_blank" rel="nofollow">PMID: 26080355</a></p>
- Sequence:
- Pal-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C104H178N26O25S2