Amylin (8-37) (human)

Amylin (8-37) (human) is a peptide fragment of amylin with the first seven amino acids removed, including the disulphide bridge, that acts as an amylin receptor antagonist.  Amylin (8-37) (human) inhibits osteoblast proliferation induced by full-length human amylin and has no agonist activity at amylin receptors. Amylin (8-37) (human) induces formation of polymorphic fibrils containing coiled and laterally-associated sheet structures and is cytotoxic to RINm5F islet β-cells in vitro when used at a concentration of 25 µM, an effect that is inversely correlated with mature fibril content.