Apelin 36 (human)
Product Sizes
Apelin 36 (human)
£259.00
AR-010
About this Product
- SKU:
- AR-010
- CAS Number:
- 252642-12-9
- Extra Details:
- Apelin-36 (human) is an endogenous apelin receptor agonist that is secreted by adipocytes. Apelin-36 (human) binds with high affinity to human apelin receptors expressed in HEK 293 cells (pIC50= 8.61) and is linked to two major types of biological activity: cardiovascular, such as stimulation of cardiac contractility and suppression of blood pressure, and metabolic, including improving glucose homeostasis and lowering body weight, and regulation of cardiovascular function, fluid homeostasis and feeding.
- Molecular Weight:
- 4195.87
- Purity:
- >95% by hplc
- References:
- <p>Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. <strong>251</strong> 471 <a href="https://pubmed.ncbi.nlm.nih.gov/9792798/" target="_blank" rel="nofollow">PMID: 9792798</a></p><p>Medhurst et al (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem.<strong> 84</strong>(5) 1162 <a href="https://pubmed.ncbi.nlm.nih.gov/12603839/" target="_blank" rel="nofollow">PMID: 12603839</a></p><p>Galon-Tilleman et al (2017) Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling. J Biol Chem. <strong>292</strong>(5):1925 <a href="https://pubmed.ncbi.nlm.nih.gov/27994053/" target="_blank">PMID: 27994053</a><br></p>
- Sequence:
- H-Leu-Val-Gln-Pro-Arg-Gly-Ser-Arg-Asn-Gly-Pro-Gly-Pro-Trp-Gln-Gly-Gly-Arg-Arg-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C184H297N69O43S