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Proteins and Peptides

AMPR-22

Product Sizes
AMPR-22
£200.00
AM-330
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
AM-330
Extra Details:
AMPR-22 is an optimised antimicrobial peptide derived from reactive oxygen species modulator 1 (Romo1), a mitochondrial protein encoded by the nucleus which is a nonselective cation channel in the mitochondrial inner membrane.  AMPR-22 shows broad-spectrum antimicrobial activity against 17 sepsis causing bacteria, including multidrug resistant (MDR) strains, by inducing membrane permeabilization.  In vivo, AMPR-22 enables a remarkable survival rate in mice injected with MDR bacteria in murine models of sepsis.
Molecular Weight:
2186.78
Purity:
>95% by hplc
References:
You et al (2021) A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria. Int J Mol Sci. <strong>22</strong>(15) 8243<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348110/" target="_blank"> PMID: 34361008</a>
Sequence:
H-Lys-Lys-Met-Met-Lys-Lys-Gly-Gly-Lys-Phe-Gly-Thr-Phe-Met-Ala-Ile-Gly-Gly-Ile-Arg-OH
Shipping Conditions:
Ambient
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Solubility:
Soluble in water
Formula:
C98H168N28O22S3