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Epirubicin HCl

SKU:
10-2761-5mg
CAS Number:
56390-09-1
Extra Details:
Antitumor agent1. Inhibits topoisomerase II2. Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking, interference with DNA unwinding, strand separation and helicase activity3. Induces myocardial disfunction as a side effect to chemotherapy4.
Molecular Weight:
579.99
Physical State:
Red orange solid
References:
1) Cersosimo et al. (1986), Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue; J. Clin. Oncol., 4 425 2) Spadari et al. (1986), DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs; Anticancer Res., 6 935 3) Minotti et al. (2004), Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity; Pharmacol. Rev., 56 185 4) Mercuro et al. (2007), Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers; Oncologist, 12 1124
Shipping Conditions:
Ambient
Storage Conditions:
-20°C
Supplier:
Focus Biomolecules
  • Manufacturer's Data Sheet:
Purity:
97% by TLC, NMR (Conforms)
Chemical Name:
4’-Epidoxorubicin
Price £125.00

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