Epirubicin HCl SKU: 10-2761-5mg CAS Number: 56390-09-1 Extra Details: Antitumor agent1. Inhibits topoisomerase II2. Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking, interference with DNA unwinding, strand separation and helicase activity3. Induces myocardial disfunction as a side effect to chemotherapy4. Molecular Weight: 579.99 Physical State: Red orange solid References: 1) Cersosimo et al. (1986), Epirubicin: a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue; J. Clin. Oncol., 4 425 2) Spadari et al. (1986), DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs; Anticancer Res., 6 935 3) Minotti et al. (2004), Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity; Pharmacol. Rev., 56 185 4) Mercuro et al. (2007), Early epirubicin-induced myocardial dysfunction revealed by serial tissue Doppler echocardiography: correlation with inflammatory and oxidative stress markers; Oncologist, 12 1124 Shipping Conditions: Ambient Storage Conditions: -20°C Supplier: Focus Biomolecules Manufacturer's Data Sheet: Purity: 97% by TLC, NMR (Conforms) Chemical Name: 4’-Epidoxorubicin Price £125.00 Qty: Add to order Hi, 2B Team here, how can we make a difference? Chat Academic Pricing Please contact us for academic pricing. Contact Us