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Bleomycin Sulfate

SKU:
10-2623-5mg
CAS Number:
9041-93-4
Extra Details:
Coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage3. Commonly used to induce lung fibrosis in animal disease models4,5. Anticancer agent in clinical use6.
Molecular Weight:
1512.62
Physical State:
White or off-white solid
References:
1) Petering et al. (1990), The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact., 73 133 2) Huttenhofer et al. (1992), Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem., 267 24471 3) Lee et al. (2017), ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks; Mol. Cell 68 61 4) Xie et al. (2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res., 17 103 5) Inomata et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res., 15 16 6) Tanaka et al. (2008) Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res., 28 2663
Shipping Conditions:
Ambient
Storage Conditions:
-20°C
Supplier:
Focus Biomolecules
  • Manufacturer's Data Sheet:
Purity:
Contains a mixture of A2 (~70%) and B2 (~30%) forms 95% by HPLC NMR: (Conforms)
Chemical Name:
From Streptomyces verticillus
Price £152.00

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