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Doxorubicin HCl

SKU:
10-2130-10mg
Additional Names:
Adriamycin, NSC-123127
CAS Number:
25316-40-9
Extra Details:
Antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Induces apoptosis in a variety of cell lines2. Substrate for MDR13. Cell permeable.
Molecular Weight:
579.99
Physical State:
Red-orange solid
References:
1) Zeman et al. (1998), Characterization of covalent adriamycin-DNA adducts; Proc. Natl. Acad. Sci., 95 11561 2) Katoh et al. (1998), Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor; Cancer Res., 58 5565 3) Perez et al. (2011), Anti-MDR-1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines; Anticancer Res., 31 2813
Shipping Conditions:
Ambient
Storage Conditions:
-20°C
Supplier:
Focus Biomolecules
  • Manufacturer's Data Sheet:
Purity:
98% by TLC, NMR (Conforms)
Price £123.00

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