Doxorubicin HCl SKU: 10-2130-10mg Additional Names: Adriamycin, NSC-123127 CAS Number: 25316-40-9 Extra Details: Antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Induces apoptosis in a variety of cell lines2. Substrate for MDR13. Cell permeable. Molecular Weight: 579.99 Physical State: Red-orange solid References: 1) Zeman et al. (1998), Characterization of covalent adriamycin-DNA adducts; Proc. Natl. Acad. Sci., 95 11561 2) Katoh et al. (1998), Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor; Cancer Res., 58 5565 3) Perez et al. (2011), Anti-MDR-1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines; Anticancer Res., 31 2813 Shipping Conditions: Ambient Storage Conditions: -20°C Supplier: Focus Biomolecules Manufacturer's Data Sheet: Purity: 98% by TLC, NMR (Conforms) Price £123.00 Qty: Add to order Hi, 2B Team here, how can we make a difference? Chat Academic Pricing Please contact us for academic pricing. Contact Us