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ALP / Alkaline Phosphatase Assay Kit

SKU:
ARG81296-250TESTS
Additional Names:
TNSALP; HOPS; EC 3.1.3.1; Alkaline phosphatase, tissue-nonspecific isozyme; TNAP; Alkaline phosphatase liver/bone/kidney isozyme; APTNAP; AP-TNAP
Application:
Cell-based/Functional Assay
CE/IVD:
For laboratory research only, not for drug, diagnostic or other use.
Extra Details:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Gene Details:
ALPL
Protein Details:
P05186
Sensitivity:
2 U/l
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C
Supplier:
Arigo Bio
Type:
Assay Kits: Detection
Size:
250 tests
Range:
5 µl serum or plasma sample: 2 - 800 U/l
Specificity:
p-nitrophenyl phosphate that is hydrolyzed by ALP into p-nitrophenol and seen as a yellow colored product and could be detect at 405 nm. This ALP activity kit measurement the color change at O.D. 405 nm for ALP activity analysis.
Synonyms:
alkaline phosphatase liver/bone/kidney isozyme;alkaline phosphatase, liver/bone/kidney;alkaline phosphatase, tissue-nonspecific isozyme;APTNAP;AP-TNAP;HOPS;HPPA;HPPC;HPPI;HPPO;liver/bone/kidney-type alkaline phosphatase;tissue non-specific alkaline phosphatase;tissue-nonspecific ALP;TNALP;TNAP;TNSALP
Price for 250 tests £696.00

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