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8 Hydroxyguanosine (8-OHdG) ELISA Kit

SKU:
ARG80911-96WELLS
Application:
ELISA
CE/IVD:
For laboratory research only, not for drug, diagnostic or other use.
Conjugate:
HRP
Extra Details:
8-hydroxy-2-deoxy Guanosine (8-OHdG) is produced by the oxidative damage of DNA by reactive oxygen and nitrogen species and serves as an established marker of oxidative stress. Hydroxylation of guanosine occurs in response to both normal metabolic processes and a variety of environmental factors (i.e., anything that increases reactive oxygen and nitrogen species). Increased levels of 8-OHdG are associated with the aging process as well as with a number of pathological conditions including cancer, diabetes, and hypertension. In complex samples such as plasma, cell lysates, and tissues, 8-OHdG can exist as either the free nucleoside or incorporated in DNA. Once the blood enters the kidney, free 8-OHdG is readily filtered into the urine, while larger DNA fragments remain in the bloodstream. Because of the complexity of plasma samples, urine is a more suitable matrix for the measurement of free 8-OHdG than plasma. Urinary levels of 8-OHdG range between 2.7-13 ng/mg creatine, while plasma levels of free 8-OHdG have been reported to be between 4-21 pg/ml as determined by LC-MS.
Sensitivity:
0.59 ng/ml
Shipping Conditions:
Blue Ice
Storage Conditions:
2-8[o]C
Supplier:
Arigo Bio
Type:
Assay Kits: ELISAs
Size:
96 wells
Range:
0.94 - 60 ng/ml
Specificity:
Cross-reactivity: 8-hydroxy-2-deoxy Guanosine (100%); 8-hydroxy Guanosine (23%); 8-hydroxy Guanine (23%); Guanosine (0.01%)
Price for 96 wells £862.00

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