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anti-CD284 / TLR4 antibody

SKU:
ARG20515-50UG
Additional Names:
CD284; CD antigen CD284; ARMD10; hToll; TLR-4; TOLL; Toll-like receptor 4
Application:
Flow Cytometry, IHC-Frozen, IHC-Paraffin, Immunocytochemistry, Immunofluorescence, Western Blot
Buffer:
PBS, 0.05% Sodium azide and 0.05% BSA
CE/IVD:
For laboratory research only, not for drug, diagnostic or other use.
Clonality:
Polyclonal
Concentration:
1 mg/ml
Extra Details:
The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Amount this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediatiors of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90kDa (6).1. JMuzio M., Natoli G. , Saccan S., Levrero M., and Mantovani A. (1998) J. Exp. Med. 187: 2097-2101.2. Medzhitov R. and Janeway C.A (1997). Cell 91: 295-298.3. Chuang T.H. and Ulevitch R.J. (2001) Biochim. Biophys. Acta 1518 (1-2): 157-161).4. Takeuchi O., et al. (1999) Immunity 11: 443.5. Poltorak A., Riccardi-Castagnoli P., Citterio S., and Butler B. (2000) Proc. Natl. Acad. Sci USA 97: 2163-2167.6. Medzhitov R., Preston-Hurlburt P. and Janeway C.A. (1997) Jr. Nature 388 (6640): 394-397.
Gene Details:
TLR4
Host:
Rabbit
Immunogen:
Synthetic peptide around aa. 420-435 of Human TLR4.
Protein Details:
O00206
Purification:
Affinity Purified
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
Arigo Bio
Type:
Antibody: Polyclonal Antibody
Size:
50 ug
Preservative:
0.05% Sodium azide
Accession:
NP_612564.1
Synonyms:
ARMD10;CD284;homolog of Drosophila toll;hToll;TLR-4;TOLL;toll like receptor 4 protein;toll-like receptor 4
Price for 50 ug £470.00

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