Skip to content

Basket

You currently have no items in your basket.

ZytoPure® FISH Probes for Lung Cancer

In situ hybridization

Zytomed Systems is proud to offer the new product line ZytoPure® FISH, a reliable and accurate tool for the detection of genetic aberrations in FFPE tissue sections, cell samples and metaphase spreads by fluorescence in situ hybridization. ZytoPure® FISH Probes display brilliant signals, low background, and an excellent signal to noise ratio. They are intended to be used in combination with the ZytoPure® FISH Accessory Kit comprising all reagents necessary for performing a FISH procedure on FFPE sections. The kit contains just 4 reagents and includes a robust and easy to follow protocol. All ZytoPure® FISH Probes as well as the ZytoPure® FISH Accessory Kit are CE/IVD-labelled.

Background information: ZytoPure® FISH Probes for lung cancer

Rearrangements of receptor tyrosine kinases (RTK) ALK, ROS1, and RET determine clinically important molecular subgroups of non-small cell lung cancer (NSCLC). About 3 % – 5 % of all NSCLCs show an ALK rearrangement, and 1 % - 2 % show ROS1 or RET rearrangements [1]. In all fusion variants, the 3´ TK domain is fused to the promotor regions and 5´ coding regions of the fusion partner. Hence, rearranged RTKs are permanently active, sending proliferation signals into the cell, and thereby promoting non-controlled cell growth.

Several very efficient TK inhibitors (TKIs) were launched in recent years [2], and as a consequence the median survival of an ALK positive NSCLC patient treated with two ALK inhibitors is now more than 5 years [3]! Amplification of the MET gene is the second most common resistance mechanism of lung adenocarcinomas against EGFR TKIs [4]. In addition, primary MET amplification is also found in a small percentage of treatment-naïve lung adenocarcinomas [5].

Product information

ZytoPure® FISH Probes for lung cancer

Description Labelling  CE/IVD Cat. No.
ALK Break Apart ZytoPure® FISH Probe green/orange F2C002
ROS1 Break Apart ZytoPure® FISH Probe  orange/green F2C003
RET Break Apart ZytoPure® FISH Probe orange/green F2C004
MET/CEP7 ZytoPure® FISH Probe green/orange F2C005

Ancillary Reagents

Description  CE/IVD  Cat. No.
ZytoPure® FISH Accessory Kit (Pepsin Solution, 4 ml; FISH Pretreatment Buffer, 500 ml; 20x FISH Wash Buffer, 2 x 50 ml; DAPI/Antifade Solution, 800 µl) FA-Kit1-20
Pepsin Solution  FA-001-004
FISH Pretreatment Buffer (rtu) FA-002-500
20x FISH Wash Buffer FA-003-050
DAPI/Antifade Solution FA-004-008
Fixogum (Rubber Cement) - ZY-FX125

We use cookies to give you the best experience of using this website. By continuing to use this site, you accept our use of cookies. Please read our Cookie Policy for more information.