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UltraMAB®

Mouse monoclonal antibodies validated with a High-Density Protein Microarray.

UltraMAB

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UltraMAB®

Some commonly used diagnostic antibodies perform well in applications but cross-react with other unrelated proteins. This cross-reactivity may potentially cause unexpected side effects and generate false diagnostic reports. OriGene is proud to announce the development of High-Density Protein Microarray for antibody specificity testing.

High-Density Protein Microarray

Antibody Specificity Validation Technology

Under current specifications, ~17,000 samples were spotted in duplicates on a single nitrocellulose slide. These include 17,000 different overexpression lysates and 708 positive and negative control samples. Serial diluted mouse, human and rabbit IgG mixture as positive controls were spotted on three subarrays highlighted in redboxes. Subarrays highlighted in yellow boxes contain serial diluted HEK293T cell lysates as negative controls. All the subarrays contain standard positive and negative controls as shown in the figure.

Using this microarray spotted with 17,000 different over-expressed proteins, we have validated the specificity of existing HER2 and ERCC1 diagnostic antibody (View publication on the validation of ERCC1 antibodies). This protein microarray technology has also been applied to identify UltraMAB®, the ultra specific antibodies for cancer biomarkers and other important diagnostic targets. Major applications of validation for UltraMAB® include.

  • Mono-specificity test
  • WB with cell lines and tissue lysates
  • IHC staining with over 25 types of normal and cancer human tissues
  • IF/ICC
  • FACS
Here are the targets we can offer UltraMAB for!
ABAT ACTA2 ADIPOQ AFP AGR2 ALDH1L1 ALK
ALX4 AMACR ANO1 AR BBOX1 BCL2 BID
BMP4 BTLA BUB1B C14orf166 CA12 CD13 CD19
CD1C CD2 CD274 CD38 CD3E CD4 CD40
CD44 CD5 CD68 CD74 CD80 CD8A CD99
CDH1 CDH2 CDX2 CHGA CRABP2 CTAG1B CTLA4
CTNNB1 CYP1A2 DDX56 DEF6 DES DOCK2 EGFR
EPCAM ERBB2 ERCC1 ERCC4 ERG EZH2 F13A1
FCER2 FCGR1A FCGR2A FGF21 FOLH1 FOS FOXP1
FOXP3 FTCD GATA3 GBA GEMIN8 GFAP GLI1
HADH HAO1 HEMGN HMBS HP ICOSLG IDO1
IRF6 JUN KIT KLK8 KRT18 KRT19 KRT20
KRT7 KRT8 L1CAM LGALS3 LGR5 MADCAM1 MAPT
MCAM MCM2 MEF2C MET MGMT MKI67 MLANA
MLF1 MLH1 MME MMP7 MRPS34 MRPS7 MS4A1
MSH2 MSH6 MSI1 MSMB MSR1 MUC1 NAPSA
NBN NCAM1 NES NKX2-1 NKX3-1 NME1 OX40
PARN PBX1 PCNA PDCD1 PDCD1LG2 PDSS2 PECAM1
PGR POU2AF1 PROCR PRPH PSMA6 PTH PYM1
RAPGEF1 RRM1 S100A9 S100P SDCBP SDHB SERPINB4
SLC7A8 SOX5 SQSTM1 SYP SYT4 TG TLE1
TNFRSF18 TNFRSF8 TNNC1 TNNT2 TOP2A TP53 TYMP
TYMS TYR UCHL1 VBP1 VIL1 VIM VISTA
VSNL1 WFDC2 WIBG XRCC1 ZSCAN18    

 

UltraMAB

The Ultra Specific Antibodies
Validated against > 10,000 Human Antigens

Further Information!

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