PathPlus™ Neuro ADGRG7 Antibody LS-A8008
This antibody is showing strong staining of astrocytes and Bergmann gliain normal human brain cerebellum.
ADGRG7 (GPR128, Adhesion G protein-coupled receptor G7) is a membrane-bound orphan receptor involved in cellular adhesion, migration, and cell-to-cell and cell-to-matrix interactions. The extracellular region of adhesion GPCRs can be exceptionally long and contain a variety of structural domains that are known for their ability to facilitate cell and matrix interactions. ADGRG7 has been suggested to have a role in intestinal absorption and musculoskeletal disorders, as well as osteochondral ossification. ADGRG7 has been shown to be modulated by ER-alpha and the Sp1 complex. LSBio’s in-house Northern blots indicated expression in liver, small intestine, and colon, and low expression in thymus, spinal cord, putamen, and medulla.