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Jellagen® 3D Scaffolds

Next Generation Jellyfish Collagen 3D Scaffolds for in vitro cell culture
and tissue engineering.

PRODUCT DESCRIPTION

3D scaffolds of jellyfish collagen, suitable for cell culture research and tissue engineering purposes.

Product Numbers

*bespoke and non cross-linked formats available on request and subject to volume

FEATURES & BENEFITS

FEATURES BENEFITS
Innovative Offers a viable alternative to mammalian and synthetic
scaffolds.
Non-mammalian Highly purified jellyfish collagen alternative providing
consistent, repeatable results.
Batch to batch consistency Offers improved research productivity allowing
security of product consistency and reproducible
results.
Cross-linked EDC cross-linked scaffolds for enhanced mechanical and
thermal stability, resorbable in vivo1.
Evolutionary ancient collagen demonstrating
sequence homology to collagen I and II
Universal applications for multiple cell types and
regenerative medicine.
Manufactured according to ISO13485 Follows a quality controlled manufacturing process
producing a consistent scaffold.
Uniform pore size Promotes cell seeding, invasion, proliferation and
differentiation. Allows for growth factor permeation
and gas exchange ensuring long-term cell survival.
Natural Scaffold Jellagen® 3D Scaffolds exhibit similar physiological
components and properties to the ECM of the in vivo
micro-environment.

The grade of Jellagen® jellyfish collagen used to manufacture these scaffolds has been tested to verify its applicability for routine cell culture research using human primary and iPSC-derived cell lines. Jellagen® Jellyfish collagen has been shown to promote cellular attachment, proliferation and differentiation to develop functional  matrices.

Cell lines that have been cultured successfully on Jellagen® jellyfish collagen include, but are not limited to: Chondrogenic progenitor cells, ovarian cancer cell lines, and iPSC-derived microglia.

Product Information Jellagen® 3D Scaffolds
Format 6, 24, 48 and 96-well scaffolds, cast in plates
Collagen Jellyfish collagen
Storage Room temperature
Serum level Serum free
Storage Store at room temperature
Shelf life Under evaluation
Plate polymer Non-tissue culture treated, polystyrene and
non-pyrogenic
Colour White to off-white
Bioburden Negative
Shipping conditions Room temperature
pH Approximately 7.0 – 7.4 when suspended in PBS or tissue
culture media

References

  1. Jonathan P. Widdowson, Alex J. Picton, Valerie Vince, Chris J. Wright, Andrew Mearns-Spragg. “In vivo comparison of jellyfish and bovine collagen sponges as prototype medical devices”. J Biomed Mater Res B Appl Biomater. 2018 May;106(4):1524-153
  2. Sourour Addad, J.Exposito, C.Faye, S.Ricard-Blum, and C. Lethias. “Isolation, Characterization and Biological Evaluation of Jellyfish Collagen for Use in Biomedical Applications”. Marine Drugs. 2011; 9(6): 967–983
  3. Xiaochen Cheng, Ziyu Shao, Chengbo Li, Lejun Yu, Mazhar Ali Raja, and Chenguang Liu “Isolation, Characterization and Evaluation of Collagen from Jellyfish Rhopilema esculentum Kishinouye for Use in Hemostatic Applications. PLoS One. 2017: 12 (1)
  4. Seiya Miura and Shigeru Kimura. “Jellyfish Mesogloea Collagen – characterisation of molecules AS α1α2α3 heterotrimers”. The Journal of Biological Chemistry. 1985. Vol. 260, No. 28,Issue of December 5, pp. 15352-15356.
  5. Eun Song, So Yeon Kim, Taehoon Chun, Hyun-Jung Byun, Young Moo Lee. “Collagen scaffolds derived from a marine source and their biocompatibility”. Biomaterials 27. 2006. 2951–2961
  6. Judith Sewing1, Matthias Klinger and Holger Notbohm., “Jellyfish collagen matrices conserve the chondrogenic phenotype in two- and three- dimensional collagen matrices.”. Journal of Tissue Engineering and Regenerative Medicine. 2015 Research Article.
  7. Birgit Hoyer, Anne Bernhardt, Anja Lode, Sascha Heinemann, Judith Sewing, Matthias Klinger, Holger Notbohm, Michael Gelinsky.” Jellyfish collagen scaffolds for cartilage tissue engineering.’ Acta Biomaterialia 10.2014. 883–892
  8. Marion Pugliano, Xavier Vanbellinghen, Pascale Schwinté, Nadia Benkirane-Jesseland Laetitia Keller. “Combined Jellyfish Collagen Type II, Human Stem Cells and Tgf-β3 as a Therapeutic Implant for Cartilage Repair.” Journal of Stem Cell Research & Therapy. 2017, 7:4
  9. Ayako Miki, Satomi Inaba, Takayuki Baba, Koji Kihira, Harumi Fukada and Masayuki Oda. “Structural and physical properties of collagen extracted from moon jellyfish under neutral pH conditions”. Bioscience, Biotechnology, and Biochemistry, 2015 Vol. 79, No. 10, 1603–1607

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