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VivopureX[TM] Recombinant Antibodies for In Vivo Research

Engineered mouse antibodies available at bulk discounts!

VivopureX™ antibodies are recombinant mouse antibodies ideal for in vivo research in mouse models. The collection consists of popular antibody clones, many originally obtained from rats or hamsters, which Absolute Antibody has engineered into mouse-anti mouse recombinant versions to improve research results.

VivopureX™ recombinant antibodies offer many advantages compared to the original monoclonal antibodies, including increased long-term efficacy, stronger potency and a more consistent response across cohorts. They also feature engineered effector functions, with Fc receptor binding tailored to best suit popular applications such as depletion, agonism or blocking.

Our VivopureX™ Antibody Collection

The VivopureX™ collection includes a selection of our most exciting mouse-anti-mouse antibodies, now available at competitively priced bulk prices. All are available in discounted bulk sizes ranging from 1 mg to 100 mg, as well as our standard 200 μg size. We’ll continue to add new antibodies, so check our website for updates.

Antibody Name [Clone] Engineered Format Top Application Available Bulk Sizes
Anti-PD-1 [RMP1-14] Mouse IgG2a Fc Silent™ Blocking 1mg, 10mg, 25mg, 100mg
Anti-CTLA-4 [9D9] Mouse IgG2a Fc Silent™ Blocking 1mg, 10mg, 25mg, 100mg
Anti-CD134 [OX86] Mouse IgG2a Agonism 1mg, 10mg, 25mg, 100mg
Anti-TIGIT [1B4] Mouse IgG1 Blocking 1mg, 10mg, 25mg, 100mg
Anti-Lag3 [C9B7W] Mouse IgG2a Blocking 1mg, 10mg, 25mg, 100mg
Anti-GITR [DTA-1] Mouse IgG2a Agonism 1mg, 10mg, 25mg, 100mg
Anti-CD25 [PC-61.5.3] Mouse IgG2a Depletion 1mg, 10mg, 25mg, 100mg
Anti-IL-10R [1B1.3a] Mouse IgG2a Fc Silent™ Blocking 1mg, 10mg, 25mg, 100mg
Anti-B7-H4 [7A1-6] Mouse IgG2a Fc Silent™ Blocking 1mg, 10mg, 25mg, 100mg
Anti-CD96 [6A6] Mouse IgG2a Fc Silent™ Blocking 1mg, 10mg, 25mg, 100mg

Engineered PD-1 Antibody

Our VivopureX™ antibodies offer many advantages compared to the original antibody format, as illustrated by our data below. In this example, our recombinant mouse PD-1 antibody based on the widely used clone RMP1-14 reduced tumor size in a mouse model more effectively than the original rat version.

  • Reduced immunogenicity: no neutralizing antibodies are induced in the host organism, meaning the antibody works for longer and cohorts respond more consistently
  • Tailored effector function: the antibody format has been engineered to suit its most popular applications
  • Increased potency: less antibody is required to achieve the same response in mouse models
  • Batch-to-batch reproducibility: recombinant production ensures the highest possible reproducibility, while guaranteeing high purity and low endotoxin levels

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