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SeLENOZYME

SeLENOZYME is a unique world-wide provider of recombinant selenoproteins for customers in academic research, pharmaceutical industry and other fields of biotechnology.

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SeLENOZYME

 

Selenozyme is a unique world-wide provider of recombinant selenoproteins. We use a cutting-edge technology, resulting from over 30 years of research at Karolinska Institutet in Stockholm, Sweden. Our recombinant system allows us to produce purified andactive selenoproteins. Our portfolio includes more than 25 selenoproteins, where we additionally have the capability to produce most other naturally occurring selenoproteins, or other tailored synthetic selenocysteine-containing proteins.

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SELENOPROTEINS

In humans, there are 25 selenoproteinencoding genes, which are involved in diverse metabolic and physiological functions ranging from antioxidant defense to fertility, muscle development and function, thyroid hormone metabolism, and immune function. Several selenoproteins also have major importance in cancer, both as enzymes protecting cells from carcinogenesis and as target proteins for anticancer drug therapies. Consequently, the range of pathologies associated with primary or secondary defects in selenoprotein functions are many.

 

 

Their Technology

Since all selenoproteins by definition contain the rare amino acid Selenocysteine (Sec), it has previously been very hard to obtain them in pure form or to produce them recombinantly, due to the complex genetic system required for co-translational Sec
insertion. After over 30 years of extensive research at Karolinska Institutet in
Stockholm, led by professor Elias Arnér and his research group, the technical challenges for producing recombinant selenoproteins have been overcome.