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AteloGene Local and Systemic Use

RNA interference (RNAi) is a mechanism in which fragments of double-strand ribonucleic acid (dsRNA) interfere with the expression of a specific gene whose sequence is complementary to the dsRNA. Recently, RNAi medicines, that inhibit the expression of genes responsible for diseases have been studied actively. However, the delivery of siRNA in vivo complicated by the siRNA being unstable in vivo. This product is a kit for delivering siRNA into animal tissues by local or systemic administration in mice and then efficiently introducing it into the cells by atelocollagen (solubilized collagen obtained by protease treatment) and transfects siRNA in vivo efficiently and safely with each local or systemic administration.